NSAIDs以优化剂量治疗中轴型SpA：聚焦6周期间骶髂关节MRI变化
PresentID:OP
原文
TREATMENTOFAXIALSPONDYLOARTHRITISWITHANOPTIMALDOSAGEOFNSAIDS:A6-WEEKFOLLOWUPSTUDYFOCUSINGONMAGNETICRESONANCEIMAGINGOFTHESACROILIACJOINTS.
G.Varkas1,*,H.Cypers1,L.VanPraet1,L.Jans2,P.Carron1,D.Elewaut1,F.VandenBosch1
1Rheumatology,2Radiology,GhentUniversityHospital,Ghent,Belgium
Background:Incontrasttotheestablishedefficacyofanti-tumornecrosisfactorα(TNFα)onBMEofthesacroiliacjoints(SIJ)(andspine),surprisinglylittleinformationexistsontheimpactofNSAIDs.AsNSAIDtherapywasalreadythecornerstoneoftreatmentbeforemagneticresonanceimagingoftheSIJwasintroduced,verylimiteddataontheeffectofoptimalNSAIDtherapyontheextentofinflammation,quantifiedbyavalidatedscoresuchastheSpondyloarthritisResearchConsortiumofCanada(SPARCC)scoringsystem,hasbeenpublished.OurgoalwasthereforetoexaminetheimpactofNSAIDuseondiseaseactivityandBMEinaninceptioncohortofnewonsetAxSpA.
Objectives:ToevaluatetheimpactoffulldoseNSAIDsontheextentandintensityofbonemarrowedemaofthesacroiliacjointsonmagneticresonanceimaginginaxialspondyloarthritis(AxSpA).
Methods:Asinglecenter,6-weekstudyinaconsecutivecohortofpatientswithclinicalsuspicionofAxSpA.Atotalofpatientswerescreened.ThirtysixpatientswithdiagnosisofAxSpAandpositiveMRISIJwereincludedforafollow-upMRIafter6weeksofoptimaldoseofNSAIDs.DiseaseactivitywasmonitoredbyaBASDAIquestionnaireevery2weeksandBASFIatbaselineandweek6.NSAIDintakewasassessedbytheASASNSAID-index.PrimaryendpointswereBASDAIresponseandimprovementoftheSpondyloarthritisResearchConsortiumofCanada(SPARCC)scoreofMRISIJatweek6.
Results:About38.5%ofAxSpApatientswasunabletocontinuethefulldoseNSAIDschedule.Sixteenpatientsabided北京治白癜风的医院哪家比较好北京白癜风的最好医院